Nexera XS inert
Бренд: Shimadzu
For many biopharmaceuticals and medium-molecule drugs, it can be difficult to acquire reliable data using a typical HPLC system, due to adsorption caused by interactions with metal ions. That tendency is particularly true for molecules that contain phosphates, carbonyl groups, or other characteristic elements or functional groups, the adsorption of which can affect analysis in various ways, such as by causing poor peak shape or inadequate sensitivity. Therefore, to increase the sensitivity and accuracy of analysis, it is important to inhibit the adsorption of compounds to the system.
In addition to the standard Nexera models made with stainless steel for excellent pressure resistance, broad applicability, and robustness, a new bioinert model has been added to the Nexera series product line. （Click here for the full nexera lineup）
Nexera XS inert UHPLC systems achieve a 105 MPa pressure capacity while inhibiting adsorption to metals by using PEEK or ceramic materials in flow channels where samples flow. They also offer excellent resistance to corrosion and a broad range of pH levels, meaning they can be operated reliably using mobile phases that contain high haloid salt concentrations or have extreme pH levels.
| Allowable maximum pressure | 105 MPa |
|---|---|
| Internal rinsing | Standard equipment (3 dil) |
| Features | Nexera XS inert combines excellent resistance to corrosion with the inertness of surfaces in contact with the sample and mobile phases. The system provides excellent chromatographic separation performances for a wide range of applications. |
| Model Name | Features | |
|---|---|---|
| System controller | SCL-40* CBM-40* CBM-40lite* |
Color screen with touch panel and system controller with reservoir tray Number of connectable units : 8 (Using option: 12) , 4(CBM-lite, Excluding built-in solvent delivery unit) Connectable unit : Solvent delivery unit: max. 4, Autosampler: 1, Column oven: max. 4, Detector: max 2, etc. |
| Solvent Delivery Pump | LC-40D XSi | Pumping method : Parallel-type double plunger (approx. 10 μL/1 stroke) Allowable maximum pressure : 105 MPa Flow rate settings range : 0.0001 to 3.0000 mL/min (1.0 to 105 MPa), 3.0001 to 5.0000 mL/min (1.0 to 80 MPa), 5.0001 to 10.0000 mL/min (1.0 to 22 MPa) Flow rate accuracy :≦± 1% (under specified conditions) Gradient mode : High-pressure gradient (2 or 3 solvents) Quaternary low-pressure gradient |
| Gradient Mixer | MR Mixer(Inert) | MR 20 µL MR 180 µL MR 40 µL LPGE MR 300 µL LPGE |
| Degassing Unit | DGU-403* DGU-405* |
Number of degassed solvents : 3(DGU-403), 5(DGU-405) Degassed low line capacity : 400 μL/1 line Operating temperature range : 4 to 35°C |
| Autosampler | SIL-40C XSi | Injection method : Total-volume Injection (standard), loop injection (optional) Allowable maximum pressure : 105 MPa Injection volume : 0.1 to 50 μL, 0.1 to 2000 μL (optional) Injection volume accuracy : ≦± 1% (5 μL injection, n = 20) Injection cycle time : ≦6.7 seconds (under specified conditions) |
| Column Oven | CTO-40S | Temperature control type : Forced air circulation Cooling Method : Electronic cooling Temperature control range : Room temperature -10 to 85 ℃（CTO-40S） Room temperature -10 to 100 ℃（CTO-40C） Temperature accuracy :±0.8℃（CTO-40S）, ±0.5℃（CTO-40C） Temperature precision : 0.2 ℃（±0.1 ℃、CTO-40S）, 0.1 ℃（±0.05 ℃、CTO-40C） |
| UV-VIS Detector | SPD-M40* Please contact your local Shimadzu representative. |
Light source : Deuterium (D2) lamp Number of diode elements : 1024 Wavelength range : 190 to 700 nm Wavelength accuracy : ≦± 1 nm Wavelength reproducibility : ≦± 0.1 nm |
| Flow Cell | UHPLC inert cell | Cell volume: 8 μL, Cell path length: 10 mm |
| Low-diffusion inert cell | Cell volume: 2.5 μL, Cell path length: 5 mm | |
| Inert cell | Cell volume: 12 μL, Cell path length: 10 mm | |
| pH monitor | pHM-40 | Measurement range：pH 1 to 14 Measurement error：pH ± 0.1 Ambient operating temperature：4 to 35 ℃ Usable humidity range：20 to 85 % |
| Mobile phase monitor | ||
| Software | Labsolutions LC/GC Multi LC-PDA, LabSolutions LCMS Please contact your local Shimadzu representative. |
|
Specification Sheet Downloads
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Nexera XS inert Specifications [ PDF / 642.77KB ]
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Nexera XS inert [ PDF / 2.32MB ]
Shim-pack HPLC Columns for Bioseparation [ PDF / 2.11MB ]
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