The 1290 Infinity III Bio Online Sample Manager combines the 1260 Infinity III Online Sample Manager and the 1290 Infinity III Bio Multisampler, offering a biocompatible flow path and a maximum pressure capability of 1300 bar for the most demanding bioprocess monitoring applications.The Online Sample Manager mediates sample diluent incompatibility in challenging bioprocess samples by supporting both flowthrough and Agilent Feed Injection methods. It automates dilutions up to 1:1000, and offers retain-sample functionality for further analysis. The system also enables direct analysis of process samples and provides automated sample preparation.