bioZen 1.7 µm Oligo, LC Column 100 X 2.1 mm, Ea

Biozen Oligo utilizes organo-silica core-shell technology to:​

• Minimize band broadening associated with diffusion and oligonucleotide mass transfer kinetics​
• Increase efficiency to produce narrower peaks, ideal for resolving closely eluting impurities​
• Patented grafting process ensures high pH and temperature resistance from ethylene cross-linking.​

LC-MS Analysis of Nusinersen

Oligos can chelate to trace heavy metals in stainless steel column hardware, leading to poor recovery, inconsistent chromatography and problematic carryover. The Biozen Oligo bio-inert hardware provides greater sensitivity as well as improved recovery, demonstrating this column’s optimal utility for oligonucleotide characterization and quantitation.

Biozen Oligo’s bioinert hardware enhances recovery, sensitivity, and chromatographic reproducibility by mitigating non-specific adsorption. Stainless steel equivalents fails to prevent this resulting in poor recovery, peak tailing, and residual carryover.​