Biozen 3 µm dSEC-7, LC Guard Column 30 x 4.6 mm, Ea
Бренд: Phenomenex
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An SEC Column for AAV Aggregate Analysis
Hydrophilic Diol-Type Surface Chemistry
Biozen dSEC-7 columns are packed with large pore silica coupled with a proprietary hydrophilic diol-type bonded surface chemistry that ensures silica surface interactions are mitigated.
Optimized Loading Capabilities
Biozen dSEC-7 offers optimized column dimensions to provide improved resolution and reproducibility at lower sample loads to reduce sample consumption.
Biozen dSEC-7 Features
Improved Loading
dSEC-7 addresses the challenge of aggregate analysis by offering accurate detection and separation with injections as low as 0.5 µL. Unlike traditional methods that demand large sample volumes, dSEC-7 conserves valuable samples, allowing for replicate analyses and ensuring availability for other CQA tests.
Mobile Phase Flexibility
dSEC-7’s particle properties facilitate robust separation of monomer from aggregate species, regardless of which mobile phase best suits your sample. This ensures reproducible results while accommodating unique sample demands, easing the burden of method condition optimization during development.
Serotype Versatility
With its robust performance and 700 Å pore size, dSEC-7 effectively resolves monomer from aggregate peaks across various AAV serotypes. This capability is crucial for evaluating appropriate serotype candidates, each varying in its unique tissue and cell tropisms, to ensure desired therapeutic outcomes are achieved.
Instrument Agnostic Performance
Despite differences in dwell volume and dispersion across various sites and departments, dSEC-7 consistently delivers robust and reproducible performance across commercially available LC instrumentation. This ensures reliable results regardless of variations in equipment, setup, or location.
Outperforms Trending Solutions
dSEC-7 excels in providing superior resolution over market alternatives, particularly when characterizing higher-level aggregates in AAV analysis. Unlike current market solutions with insufficient particle pore size, dSEC-7 ensures accurate and reproducible separation of AAV monomer from aggregates.
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