CD57 (Dako Omnis)

CD57 is expressed by subsets of NK cells and CD8+ lymphocytes, and by a small percentage of CD4+/CD45R0+ T lymphocytes in lymph node germinal centres. The number of CD57+ cells increases in some pathologies characterized by an imbalance of CD4/CD8 lymphocytes. Normal neuroectodermal cells and striated muscle also express CD57. Antibodies to CD57 have been shown to aid in classification of T-cell large granular lymphocyte disorders, oligodendrogliomas and neuroendocrine tumors, and inclassification of lymphocyte predominant Hodgkin’s lymphoma.