GeneMorph II Random Mutagenesis Kits produce highly uniform mutational spectra when performing error-prone PCR. This makes achieving random mutagenesis faster and easier. Alternative methods relying on Taq DNA polymerase have shown biases towards mutating A’s and T’s more frequently than G’s and C’s, skewing representation of random mutant libraries.GeneMorph II kits utilize Mutazyme II DNA polymeraseA novel error-prone PCR enzyme blend with equivalent mutation rates at A’s and T’s vs. G’s and C’s.This method performs targeted random mutagenesis on protein domains and promoter elements, eliminating the need for specific restriction sites.