Gross Cystic Disease Fluid Protein-15 (Dako Omnis)

Gross cystic disease fluid protein-15 (GCDFP-15) is a 15 kDa monomeric secretory glycoprotein encoded by the prolactin-inducible protein (PIP) gene. GCDFP-15 is a marker of apocrine differentiation, and is expressed in breast cystic fluid as well as in apocrine, lacrimal, ceruminous, Moll’s and eccrine glands. Antibodies to GCDFP-15 are a useful aid for classification of breast carcinoma and metastatic tumors of breast origin.