The Waters GTxResolve 2000 Å SEC column, MaxPeak Premier 3 µm is designed with low-adsorption MaxPeak hardware and advanced bridged ethylene HO-PEO particles. This innovative composition ensures high recovery for GTx drugs ranging from 800 to 2500 Å in diameter, including lipid nanoparticles (LNPs), plasmids, and viral vectors. Engineered for extended column lifetimes, minimal secondary interactions, and enhanced MALS sensitivity, this solution supports the development of multi-attribute platform methods. It enables comprehensive integrity and heterogeneity analyses of LNP formulations, plasmid topology assessments, and improved detection of ejected transgenes and aggregates in viral vector applications.
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Chemistry
SEC
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Separation Mode
SEC
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Particle Substrate
Silica
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pH Range Min
2.5 pH
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pH Range Max
8 pH
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Temperature Limits
60 C
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Maximum Pressure
2000 psi (140 Bar)
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Endcapped
No
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Bonding Technology
SEC
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Silanol Activity
Low
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Particle Shape
Spherical
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Particle Size
3 µm
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Endfitting Type
Parker-style
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Pore Size
2000 Å
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Format
Premier Column
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Surface Area
19
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System
UHPLC, UPLC, HPLC
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Particle Technology
Silica
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Technique
SEC
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USP Classification
L33
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Inner Diameter
4.6 mm
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Length
150 mm
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Carbon Load
1.2 %
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UNSPSC
41115709
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Application
Gene Therapeutics
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Brand
GTxResolve
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Product Type
Columns
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Units per Package
1 pk
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eConnect
No